I lost 7 stone and got my life back thanks to COCH's 'incredible' Clinical Research Trial
A groundbreaking clinical research trial at the COCH has transformed the life of a man who lost an astonishing seven stone after taking part in the programme.
Matthew Hopley, 25, had tried countless diets after struggling with weight loss for years and desperately wanted to find a permanent solution to live a healthier lifestyle.

When he was contacted by the Trust's research team about a research trial for GLP-1 medication after seeking weight loss help from his GP, Matthew decided to take a leap of faith – never believing it would completely transform his life.
He says the trial, which consisted of Matthew undertaking weight loss injections to block hunger cravings and prevent over-eating, exceeded his expectations, delivering 'incredible' physical and mental health benefits, whilst helping him regain control of his life.
"The whole process was so well laid out and from the start I knew exactly what to expect," recalls Matthew.
"The team provided me with a detailed document outlining every objective and procedure. Dates for my appointments were clearly scheduled, which made it easy to manage my work and personal commitments and each upcoming step was always explained so I felt completely informed," he said.
And Matthew has nothing but praise for the support he received from the team - with someone available to give him advice day and night via email or phone.
"Their support and encouragement were key to my success," he added.
Whilst the trial was overwhelmingly positive, Matthew did face some challenges along the way, in the form of side effects, particularly when moving to higher doses of medication.
But the team had prepared him for all eventualities and gave him advice and medication to manage symptoms.
"I also struggled with my mental health at times, but their constant support got me through the toughest moments," he said.
Matthew's determination, combined with the trial's structure and support, led to extraordinary results and over the course of the trial he lost seven stone - a result he had never thought possible.
"I went in with low expectations because I didn't want to be disappointed. I thought maybe I'd lose a few pounds, but this has changed my life completely.
"I can now walk without breaking a sweat, my anxiety and depression have improved so much and my self esteem is higher than it's ever been," he said.
"The trial also helped me to develop better habits. Regular check-ups and dietitian appointments taught me how to manage cravings and make healthier choices. "
Reflecting on his experience, Matthew expressed his gratitude to the COCH research team, describing them as 'absolute professionals and truly amazing people'.
"They kept me informed, supported me every step of the way and were always there when I needed them. I couldn't have done it without them."
And to others considering a clinical trial, Matthew's message is to 'just do it'.
"The risks are low and the rewards can be life-changing,” he said. “This trial has given me my life back and I’d go on the medication again in a heartbeat. It's given me a second chance to live the life I always wanted."
Published: 11/12/2024